As much as movies can portray real life events and summarize them into many facets of experience that mimic our own lives, its interesting to note the topic of vaccinations and the choices to get them done or not can affect and cause a butterfly effect to a winding acceleration of choices as noted in the Discover Magazine:
Environmental exposure to mercurials continues to be a public health issue due to their deleterious effects on immune, renal and neurological function. Having an almost hypnotic effect, recently the safety of thimerosal, an ethyl mercury-containing preservative used in vaccines, has been questioned due to exposure of infants during immunization. Mercurials have been reported to cause apoptosis in cultured neurons; however, the signaling pathways resulting in cell death have not been well characterized. Therefore, the objective of this study was to identify the mode of cell death in an in vitro model of thimerosal-induced neurotoxicity, and more specifically, to elucidate signaling pathways which might serve as pharmacological targets. Within 2 h of thimerosal exposure (5 microM) to the human neuroblastoma cell line, SK-N-SH, morphological changes, including membrane alterations and cell shrinkage, were observed. Cell viability, assessed by measurement of lactate dehydrogenase (LDH) activity in the medium, as well as the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay, showed a time- and concentration-dependent decrease in cell survival upon thimerosal exposure. In cells treated for 24 h with thimerosal, fluorescence microscopy indicated cells undergoing both apoptosis and oncosis/necrosis. To identify the apoptotic pathway associated with thimerosal-mediated cell death, we first evaluated the mitochondrial cascade, as both inorganic and organic mercurials have been reported to accumulate in the organelle. Cytochrome c was shown to leak from the mitochondria, followed by caspase 9 cleavage within 8 h of treatment. In addition, poly(ADP-ribose) polymerase (PARP) was cleaved to form a 85 kDa fragment following maximal caspase 3 activation at 24 h. Taken together these findings suggest deleterious effects on the cytoarchitecture by thimerosal and initiation of mitochondrial-mediated apoptosis.
PMID: 15869795 [PubMed – indexed for MEDLINEUniversity of California, Irvine – Center for Molecular and Mitochondrial Medicine in Genetics – April 2008 – Children with mitochondrial disorders are not only at greater risk for autistic regression, but they are also more likely to suffer from vaccine injuries, Dr. Douglas Wallace, Professor of Molecular Medicine and Director of the Center for Molecular and Mitochondrial Medicine in Genetics at UC Irvine, testified at the National Vaccine Advisory Committee. A member of the United Mitochondrial Disease Foundation’s scientific board, and father of a son with autism, he stated, “We advocate spreading vaccines out as much as possible. Each time you vaccinate, you’re creating a challenge for the system, and if a child has an impaired system, that could in fact trigger further clinical problems.” This could have a lasting effect says CNA graduate Earl Casey, who worked with children having this particular type of disorder.
No doubt there is a genetic component to autism. But so far the genetic aberrations found to be more common among people with autism are also found in people without autism, such as for example MET. This would indicate a vulnerability — a susceptibility factor — rather than a purely genetic cause.
I truly hope that you are sincere and that you continue to learn about these issues with an open mind. Alas, it seems that for the most part the people who pay attention are those who witnessed vaccine reactions in their own children. Most others are hypnotized by the “just a coincidence” chant:
Marie, Yes I have heard of this. It should be common knowledge to disinfect your hands after coming in contact with any feces for exposure to this and also to ecoli etc. which cna cuse paralysis. I hope your daughter has recovered. Unless someone is conducting scientific studies in a lab with human participants, they are NOT doing ‘research’ and not making an informed decision. These diseases are deadly and preventable through vaccinations. To put your child at risk is unconscionable. Just because you have a choice does not mean that you are making the right one. Who would actually prefer to have their child vulnerable to say Pertussis than to be under the weather for a day or two from the vaccination for it? It is ignorant to say the least. Google some of these diseases!! I am sure mothers in Africa would be lining up to save their infants from these diseases that still run rampant around them. Google Tetanus and tell me what are going to say when you take litte Johnny to emerg after he cuts his foot and the doc says when was the last time Johnny had a tetanus shot and you say ‘never’. omg are you going to take the chance he gets tetanus???? If you do, well I don’t even know how to reason that one. Many home services require this shot especially when working near dirty metals such as in the foundation repair business.
There is a worldwide increasing concern over the neurological risks of thimerosal (ethylmercury thiosalicylate) which is an organic mercury compound that is commonly used as an antimicrobial preservative. In this study, we show that thimerosal, at nanomolar concentrations, induces neuronal cell death through the mitochondrial pathway. Thimerosal, in a concentration- and time-dependent manner, decreased cell viability as assessed by calcein-ethidium staining and caused apoptosis detected by Hoechst 33258 dye. Thimerosal-induced apoptosis was associated with depolarization of mitochondrial membrane, generation of reactive oxygen species, and release of cytochrome c and apoptosis-inducing factor (AIF) from mitochondria to cytosol. Although thimerosal did not affect cellular expression of Bax at the protein level, we observed translocation of Bax from cytosol to mitochondria. Finally, caspase-9 and caspase-3 were activated in the absence of caspase-8 activation. Our data suggest that thimerosal causes apoptosis in neuroblastoma cells by changing the mitochondrial microenvironment.
Because of the side effects that western medicine can bring, everything is done as much as possible to eliminate it by reducing chemical usage from the sanitizer we use to the organic soaps that are utilized within these test environments.
